Sheau Ling Lee 李小玲 副研究員

The research focuses in Dr. Lee’s lab aim to identify cellular/molecular properties of neural stem cell niches in brain, investigate the regulatory mechanisms/communications between neural stem cells and their niches, elucidate their roles in neural regeneration and the impacts of their dysfunction in neurodegeneration, and to develop means manifesting brain regeneration for the therapy of brain degeneration. Dr. Lee’s lab showed that a neuronal transmembrane serine protease (MTP) is critical for maintenance of brain neural stem/progenitor cell, neuronal differentiation, neural stem/progenitor cell migration, neural stem/progenitor cell bioenergetics, ischemic stress defense, and most importantly, the communication with vascular niche in brain neurogenic regions through physical interaction with a brain endothelial adhesion molecule (MCAM). Dr. Lee’s lab demonstrated that the type II diabetes medicine gliptins have therapeutic benefits against brain degeneration. The various gliptins may preferentially function on anti-inflammation or protection against neurogenic aberrance.

EDUCATION / 學歷

1996 Ph.D., Biochemistry and Molecular Biology, Univ. Oklahoma Health Science Center

EXPERIENCE / 經歷

2013 – present Associate Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
2008 Assistant Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
2005 Assistant Investigator, StemCellResearchCenter, National Health Research Institutes, Zhunan, Taiwan
2001 Research Instructor, Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, DC, U.S.A.
1999 Postdoctoral Fellow, Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, DC, U.S.A.
1997 Postdoctoral Fellow,Henry Hood Research Program, Weis Center for Research, Pennsylvania State University College of Medicine, Danville, PA, U.S.A.

LAB MEMBER / 研究團隊

姓名 職稱 分機 E-mail
洪鈺雯 博士後研究員 37512 ywhung@nhri.edu.tw
董秀蕙 研究助理 37512 hhtung@nhri.edu.tw
馮彥婷 研究助理 37512 100809@nhri.edu.tw

 

PUBLICATIONS / 論文著作

PubMed Search

NHRI Institutional Repository國家衛生研究院機構典藏

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