Prof. Chuu’s research focus on the study of the molecular mechanisms regulating the disease progression of prostate cancer (PCa), as well as the development of novel therapeutic strategy for advanced PCa. Prof. Chuu’s lab studies the roles of androgen receptor (AR) signaling, epigenetic regulatory proteins, and liver X receptor (LXR) signaling in cancer metastasis, the development of castration-resistant prostate cancer (CRPC), cancer metabolism rewiring, cancer stemness, and the development of resistance against docetaxel, enzalutamide or abiraterone acetate in PCa using human cell lines, animal models, and clinical samples in collaboration with urologists from KMU, TVGH, and TAFGH. Prof. Chuu collaborates with the Medical Research Council of South Africa to investigate the application of green rooibos (Aspalathus linearis) extract (GRT) on regulation of gut microbiota, prevention of diabetes, and its anticancer effects on PCa. For the institutional mission of cardiovascular research, Prof. Chuu’s lab investigates the effects of GRT, caffeic acid phenethyl ester (CAPE), and Taiwanese green propolis on prevention of inflammation or ischemia of blood vessels as well as hypercholesterolemia. Prof. Chuu setup the second Micro-Western Array (MWA) system, a high-throughput Western blotting array, in the world in NHRI core facility. Prof. Chuu’s lab uses MWA for research on cancer biology, cardiovascular diseases, and Alzheimer’s disease.
EDUCATION / 學歷
| 2000/09 – 2005/06 | Ph.D.,Committee on Cancer Research, The University of Chicago, Chicago, IL, USA |
| 1993/09 – 1997/06 | B.S. major, Physics Department, National Tsing Hua University, Hsinchu, Taiwan |
EXPERIENCE / 經歷
| 2020/03 – 2022/02 | Acting Chief, Office of Student Affairs, National Health Research Institutes,Zhunan, Taiwan |
| 2016/08 – present | Adjunct Associate Investigator, National Defense Medical Center |
| 2016/07 – present | Adjunct Associate Professor, Biotechnology Center, National Chung Hsing University, Taichung City, Taiwan |
| 2015/07 – present | Associate Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan |
| 2013/02 – present | Adjunct Assistant Professor, Graduate Institute of Basic Medical Science, China Medical University,Taichung, Taiwan |
| 2010/01 – present | Supervisor PI, Core Instrument Center Micro-Western Array core Lab,, National Health Research Institutes, Zhunan,Taiwan |
| 2009/09 – 2015/06 | Assistant Investigator, Institute of Cellular and System Medicine,National Health Research Institutes,Zhunan, Taiwan |
| 2005/07 – 2009/09 | Postdoctoral Scholar, Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA |
| 1999/09 – 2000/05 | Teaching Assistant/Ph.D. program student, Physics Department, Purdue University, West Lafayette, IN, USA |
| 1997/07 – 1999/06 | Second Lieutenant Instructor, Division of Vehicle Maintenance, Army Armed Force Training College, Hsinchu, Taiwan |
LAB MEMBER / 研究團隊
| 姓名 | 職稱 | 分機 | |
|---|---|---|---|
| 霍捷 | 博士後研究員 | 37516 | jason429w@nhri.edu.tw |
| 郭盈妤 | 博士後研究員 | 37516 | jennykuo0101@yahoo.com.tw |
| 汪碧娟 | 研究助理 | 37516 | bijuanwang@nhri.edu.tw |
| 汪雅珮 | 研究助理 | 37516 | yp0610@nhri.edu.tw |
| 傅榆格 | 研究助理 | 37516 | Mandy1127@nhri.edu.tw |
| 阿斯拉 | 中央大學碩士生 | 37516 | asra.789654b@gmail.com |
| 林展任 | 清華大學碩士生 | 37516 | zlin6489@gmail.com |
HONOR & AWARDS/ 榮譽獎項
| 2021 | National Innovation Award /第十八屆國家新創獎 |
| 2017 | NHRI Young Investigator Award /國家衛生研究院年輕學者獎 |
| 2011-2012 | Marquis Who is Who in Medicine and Healthcare /馬奎斯世界名人錄 (醫學健康科學領域) |
| 2011 | Marquis Who’s Who /馬奎斯世界名人錄 (不分領域) |
| 2009 | Scholarship, Essentials of Human Embryonic Stem Cell Culture Techniques National Institute of Health (NIH), U.S.A./ 美國國家衛生院人類幹細胞培養技術獎學金 |
| 2008-2009 | Postdoctoral Fellowship, Committee on Cancer Biology, The University of Chicago /美國芝加哥大學博士後研究員研究獎助 |
| 2008-2009 | Postdoctoral Research Abroad Program Grant, National Science Council, Taiwan /國科會海外博士後研究員研究計畫獎助 |
| 2000-2002 | Women’s Board Fellowship, Committee on Cancer Research, University of Chicago /芝加哥大學婦女基金會癌症研究獎學金 |
| 1996 | 3rd rank for national physics comprehension examination for college students in physics major, Taiwan /教育部全國大專物理能力測驗全國第三 |
| 1993-1997 | Fellowship for distinguished college student in physics major, Department of Education, Taiwan / 教育部資優保送獎學金 |
PUBLICATIONS / 論文著作
NHRI Institutional Repository國家衛生研究院機構典藏
