Cheng Chin Kuo 郭呈欽 研究員

Inflammation is an old concept with new definitions. Its molecular and cellular mechanisms have advanced rapidly which have revolutionized its biomedical significances and applications. Inflammation is caused by excessive and inappropriate innate immune activity such as an overwhelming activation of Toll-like receptors-signaling; it is now considered as a fundamental process in many human diseases and health issues such as cardiovascular diseases, inflammatory diseases, and cancer. Cellular and molecular factors responsible for inflammation in the diverse health problems and diseases are complex and not necessarily identical. Understanding inflammation and inflammatory signaling in the pathogenesis of disease progression will help the development of specific therapies that can effectively fight inflammatory diseases. Although the causes of inflammatory diseases are complex, however, it is becoming recognized that epigenetic, abiotic, metabolic and biotic environmental factors play a significant role. Furthermore, many modern diseases are the results of subtle metabolic imbalances related to inflammation. We thus have expanded our investigation into metabolic control of inflammation and inflammatory signaling. Our research is to use comparative metabolomics analysis coupled with molecular cellular biochemical approaches, animal models, and clinical samples to determine physiological relevance and pathophysiological connection between physiological metabolites and inflammatory diseases such systemic inflammation, cancer, and cardiovascular diseases.

EDUCATION / 學歷

1997 – 2001 Ph.D., Life Science, National Defense Medical Center, Taipei.,Taiwan
1995 – 1997 M.S., Biochemistry, National Defense Medical Center, Taipei., Taiwan
1991 – 1995 B.S., Nutrition and Food Sciences, Fu Jen Catholic University, Taipei, Taiwan

EXPERIENCE / 經歷

2020/04 – present Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
2013 – 2020 Associate Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
2008 – 2012 Assistant Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
2007 – 2008 Assistant Investigator, Cardiovascular and Blood Medical Research Center, National Health Research Institutes, Zhunan, Taiwan
2006 – 2007 Postdoctoral Fellow, Agricultural Biotechnology Research Center, Academia Sinica
2001 – 2006 Postdoctoral Fellow (substitute of military service), Institute of BioAgricultural Science, Academia Sinica

LAB MEMBER / 研究團隊

姓名 職稱 分機 E-mail
吳京穎 博士後研究員 38315 jywu@nhri.edu.tw
方嘉勳 博士後研究員 38315 100418@nhri.edu.tw
温琇婷 研究助理 38315 n87529@nhri.edu.tw
廖彩蓮 研究助理 38315 tsailien0@nhri.edu.tw
陳冠叡 研究助理 38315 ray830704@nhri.edu.tw
甘翊穎 國防大學博班生 38315 tom.kaniy@nhri.edu.tw
李柏勳 清華大學碩班生 38315 pohsun0530@gmail.com

HONOR & AWARDS/ 榮譽獎項

 

PUBLICATIONS / 論文著作

 

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NHRI Institutional Repository國家衛生研究院機構典藏

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