Shaw Fang Yet 林秀芳 研究員

Our laboratory has a long-standing interest in cardiovascular disease, including atherosclerosis, restenosis, and aneurysm. Our goal is to identify genes and mediators that serve cytoprotective functions in protecting cardiovascular system. In response to arterial wall injury, vascular smooth muscle cells (VSMCs) in the blood vessel wall dedifferentiate, migrate, and proliferate, leading to lesion formation and occlusive vascular disease. Understanding the regulation and function of genes expressed in VSMCs will provide insights into the mechanisms of VSMC-specific expression and phenotypic modulation, and the development of vascular disease.
In response to pathological stress, intrinsic defense mechanisms of the body are critical in protecting tissues from injury. Heme oxygenase-1 (HO-1) is such an inducible stress response protein. By degrading the oxidant heme and generating the antioxidant bilirubin and anti-inflammatory molecule carbon monoxide, HO-1 protects cardiovascular system against pathological stress. In addition, we have identified an unexpected role of HO-1 in stem cell differentiation.
Pluripotent stem cells (PSCs), including embryonic and induced pluripotent stem cells, can self-renew and proliferate indefinitely and differentiate into cells of all three germ layers. Therefore, PSCs are attractive sources for regenerative purposes. We are interested in using PSCs in tissue engineering to develop innovative alternative therapeutic strategy for tissue revascularization and regenerative medicine.

EDUCATION / 學歷

1982 – 1988 Ph.D., Biology, University of Houston,Houston, TX, USA
1978 – 1980 M.S., Plant Physiology, National Taiwan University, Taipei, Taiwan
1973 – 1977 B.S., Botany, National Taiwan University,Taipei, Taiwan

EXPERIENCE / 經歷

2017/09 – present Director, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
2016/05 – 2017/08 Acting Director, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
2014/07 – 2016/05 Deputy Director, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
2012/09 – 2014/06 Acting Director, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
2012/01 – present Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
2008 – 2011 Associate Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
2007 – 2008 Associate Investigator, Cardiovascular and Blood Medical Research Center, National Health Research Institutes, Zhunan, Taiwan
2004 – 2007 Assistant Professor of Medicine, Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
2000 – 2004 Instructor in Medicine, Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
1995 – 1999 Research Associate, Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, MA, USA
1991 – 1994 Research Fellow, Nutrition, Harvard School of Public Health, Boston, MA, USA
1989 – 1991 Research Fellow, Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, TX, USA

LAB MEMBER / 研究團隊

姓名 職稱 分機 E-mail
陳忠煌 博士後研究員 38308 lockecch@nhri.edu.tw
蔣偉程 博士後研究員 38308 wcjiang@nhri.org.tw
陳倩玫 博士後研究員 38308 060714@nhri.edu.tw
林真宇 研究助理 38308 060131@nhri.edu.tw
賀華慧 研究助理 38308 legend8240@nhri.edu.tw
龔珮瑜 研究助理 38308 pygung@nhri.edu.tw
王竣彥 研究助理 38308 080602@nhri.edu.tw
Candra D Hamdin 禾汀 中央博班生 38308 cdh@nhri.edu.tw

HONOR & AWARDS/ 研究團隊榮譽獎項

2022 Postdoctoral Fellow Wei-Cheng Jiang(蔣偉程) received MOST 2022 Postdoctoral Research Academic Research Award
2021 PhD student Candra D Hamdin (禾汀) received 2021 NHRI-NCU Joint Research Conference Excellent Poster Award, third place
2021 Postdoctoral Fellow Wei-Cheng Jiang(蔣偉程) received 2021 NHRI Research Day Excellent Poster Award
  Postdoctoral Fellow Chen-mei Chen(陳倩玫) received 2021 NHRI Research Day Excellent Poster Award
2020 Postdoctoral Fellow Chung-Huang Chen(陳忠煌) received 2020 NHRI Research Day Excellent Poster Award
  Research Assistant Chen-Yu Lin(林真宇) received 2020 NHRI Research Day Excellent RA Award
2019 Postdoctoral Fellow Wei-Cheng Jiang(蔣偉程) received 2019 NHRI Research Day Excellent Poster Award
2018 Postdoctoral Fellow Wei-Cheng Jiang(蔣偉程) received 2018 NHRI Research Day Oral Excellent Paper Award

 

PUBLICATIONS / 論文著作

PubMed Search

NHRI Institutional Repository國家衛生研究院機構典藏

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