Cheng Chin Kuo 郭呈欽 研究員
Inflammation is an old concept with new definitions. Its molecular and cellular mechanisms have advanced rapidly which have revolutionized its biomedical significances and applications. Inflammation is caused by excessive and inappropriate innate immune activity such as an overwhelming activation of Toll-like receptors-signaling; it is now considered as a fundamental process in many human diseases and health issues such as cardiovascular diseases, inflammatory diseases, and cancer. Cellular and molecular factors responsible for inflammation in the diverse health problems and diseases are complex and not necessarily identical. Understanding inflammation and inflammatory signaling in the pathogenesis of disease progression will help the development of specific therapies that can effectively fight inflammatory diseases. Although the causes of inflammatory diseases are complex, however, it is becoming recognized that epigenetic, abiotic, metabolic and biotic environmental factors play a significant role. Furthermore, many modern diseases are the results of subtle metabolic imbalances related to inflammation. We thus have expanded our investigation into metabolic control of inflammation and inflammatory signaling. Our research is to use comparative metabolomics analysis coupled with molecular cellular biochemical approaches, animal models, and clinical samples to determine physiological relevance and pathophysiological connection between physiological metabolites and inflammatory diseases such systemic inflammation, cancer, and cardiovascular diseases.
EDUCATION / 學歷
| 1997 – 2001 |
Ph.D., Life Science, National Defense Medical Center, Taipei.,Taiwan |
| 1995 – 1997 |
M.S., Biochemistry, National Defense Medical Center, Taipei., Taiwan |
| 1991 – 1995 |
B.S., Nutrition and Food Sciences, Fu Jen Catholic University, Taipei, Taiwan |
EXPERIENCE / 經歷
| 2020/04 – present |
Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan |
| 2013 – 2020 |
Associate Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan |
| 2008 – 2012 |
Assistant Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan |
| 2007 – 2008 |
Assistant Investigator, Cardiovascular and Blood Medical Research Center, National Health Research Institutes, Zhunan, Taiwan |
| 2006 – 2007 |
Postdoctoral Fellow, Agricultural Biotechnology Research Center, Academia Sinica |
| 2001 – 2006 |
Postdoctoral Fellow (substitute of military service), Institute of BioAgricultural Science, Academia Sinica |
LAB MEMBER / 研究團隊
HONOR & AWARDS/ 榮譽獎項
