Pu Ste Liu 劉卜慈 助研究員

Our research aims to decipher how metabolic alterations of macrophage orchestrate immune responses in chronic inflammatory diseases, with a special focus on metabolic syndromes (type II diabetes, insulin resistance and atherosclerosis) and cancer. We integrate transcriptomic, metabolomic and epigenomic approaches to identify the metabolic checkpoints and mechanisms underlying the regulation of macrophage activation and functions during disease progression, particularly in specialized microenvironment such as adipose tissues in diabetes mellitus, the arterial microenvironment in atherosclerosis and tumor microenvironment. Understanding the metabolic-immunity circuits of macrophage in the pathogenic microenvironment can pinpoint the key regulators contributing to the progression of these metabolic disorders. Our final goal is to formulate novel strategies targeting immunometabolic circuits in adipose tissue macrophages and atherosclerotic macrophages and ameliorate these chronic metabolic disorders.

EDUCATION / 學歷

2003 – 2010 Ph.D., Medical Sciences, National Cheng Kung University, Tainan, Taiwan
2000 – 2002 M.S., Biochemistry and Molecular Biology, National Cheng Kung University, Tainan, Taiwan
1996 – 2000 B.S., Medical Laboratory Science Biotechnology, China Medical University, Taichung,Taiwan

EXPERIENCE / 經歷

2018/09 – present Assistant Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
2015/09 – 2018/05 Postdoctoral Fellow, Department of Fundamental Oncology, University of Lausanne, Ludwig Center for Cancer Research, Epalinges, Switzerland
2011/09 – 2014/09 Postdoctoral Fellow, Department of Pharmacology, School of Medicine Minneapolis, University of Minnesota, MN, USA
2010/08 – 2011/08 Postdoctoral Fellow, Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
2002/09 – 2003/08 Research Assistant, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

LAB MEMBER / 研究團隊

姓名 職稱 分機 E-mail
石佩主 研究助理 37313 Sh3429751@nhri.edu.tw
溫慧勤 研究助理 37313 huichin@nhri.edu.tw
陳皙 研究助理 37313 Lunachen@nhri.edu.tw

 

PUBLICATIONS / 論文著作

PubMed Search

NHRI Institutional Repository國家衛生研究院機構典藏

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